Systemic Lupus Erythematosus

What is Systemic Lupus Erythematosus (SLE)?

Systemic Lupus Erythematosus (SLE), also known as Lupus, is a chronic autoimmune disorder in which the body’s immune system attacks its organs. The immune system of one’s body attacks its healthy tissue causing widespread tissue damage and inflammation. Systemic Lupus Erythematosus can affect the skin, joints, kidneys, brain, and various other organs. It is the most common type of lupus. It can range from mild to life-threatening conditions. It occurs in all age groups including children; however, it mostly occurs in women in the adolescent and postmenopausal age group.

Causes

The primary cause of systemic lupus erythematosus is genetic mutations. Other factors include environmental triggers, such as exposure to ultraviolet rays, being on certain medications, viruses and exposure to chemical and pollutants, which can also result in SLE development. It affects more women when compared to men and it is believed that hormonal changes also play a role in the development of this condition.

Risk factors

A positive family history of lupus in at least one first degree relative such as parents or siblings increases the risk of developing the disorder. Hormonal changes and being on certain medications can also increase the risk of developing the condition.

Symptoms & signs

Individuals having systemic lupus erythematosus may sometimes have worsening episodes and sometimes have mild episodes. Symptoms change with time. Some of the signs and symptoms that an individual experiences include the following.

• Severe fatigue
• Headaches
• Arthritis, joint pain, and swelling
• Butterfly rash, especially on the cheeks and nose
• Hair loss
• Blood clotting problems
• Anemia
• Raynaud’s phenomenon (poor circulation to the fingers and toes with cold exposure)
• Photo(sun)sensitivity
• Oral ulcers
• Seizures
• Psychosis
• Immunological problems
• Lung, heart, and kidney problems
• Appetite loss

In some individuals, symptoms flare up and sometimes go away. Therefore, individuals have periods of flare-ups as well as remissions.

Diagnosis

It is difficult to diagnose because symptoms resemble many other conditions. Therefore, findings on a thorough physical examination along with results of the investigation tests are considered while establishing a diagnosis of Systemic Lupus Erythematosus. Almost 100% patients will have ANA(Antinuclear antibody)test positive. Other investigations include routine investigations and also depend on organ manifestations.

Treatment options

Medical treatment

There is no treatment for systemic lupus erythematosus. Treatment only focuses on controlling symptoms. The goal of the treatment of the condition is to prevent organ damage and achieve complete remission.

• Medical treatment includes:
• Anti-inflammatory medications are prescribed to help with joint pain and stiffness. These drugs also help to reduce inflammation
• Steroid ointments for skin rashes
• Corticosteroids to minimize the immune response
• Antimalarial drugs for skin and joint problems
• Immunosuppressants

Role of Diet/ Exercise/ Lifestyle changes/ Preventive measures

Since the exact cause of the condition is not known, it cannot be prevented. Patient education, physical and lifestyle measures play a vital role in Systemic Lupus Erythematosus management. The following measures can help to lead a better life by controlling the symptoms.

• Consume a healthy diet:
• Minimize stress levels by following stress reduction techniques
• Good sleep hygiene
• Physical exercises
• Smoking cessation. Smoking worsens Systemic Lupus Erythematosus symptoms
• Appropriate skincare is essential for curing skin rash as well as avoiding the further breakdown of the skin
• Aerobic exercises can help to decrease fatigue levels, which can including walking, swimming, and cycling
• Physical therapy to protect joints from getting damaged

Complications

It causes damage to all systems in the body. Some of the complications that are associated with this condition include:

• Inflammation of the heart
• Heart attack
• Stroke
• Blood clots and inflammation of blood vessels
• Memory changes
• Behavioural changes
• Inflammation of the lungs, kidneys, kidney dysfunction, and kidney failure
• Pregnancy complications including miscarriage
• Osteoporosis
• Limited physical and mental functioning
• Extreme fatigue
• Pregnancy complications

Prognosis

Most of the individuals with systemic lupus erythematosus lead a normal life with treatment. The prognosis varies from person to person. The overall outcome of the disease is highly variable ranging from permanent remission to death.  

When to contact the doctor? / How to identify complications?

Treatment of systemic lupus erythematosus is effective when it is started in the early stages of the disease. Therefore, it is always recommended to consult a physician after noticing any of the symptoms associated with the condition.

Suggested clinical specialists/ Departments to consult for this condition

• Rheumatology